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CAS

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N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline is a chemical compound that serves as an intermediate in the synthesis of Linezolid (L466500), a prototype of the oxazolidinone antimicrobials. N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline plays a crucial role in the development of pharmaceuticals targeting bacterial infections by inhibiting bacterial mRNA translation.

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  • High quality N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline supplier in China

    Cas No: 874340-08-6

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  • 2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione

    Cas No: 874340-08-6

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  • 874340-08-6 Structure

  • Basic information

    1. Product Name: N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline
    2. Synonyms: N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline;2-[(2R)-3-[[3-Fluoro-4-(4-Morpholinyl)phenyl]aMino]-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione;2-[(2R)-3-[[3-Fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]-1,3-isoindolinedione;Linezolid DesacetaMide Descarbonyl PhthaliMide;(R)-2-(3-((3-Fluoro-4-morpholinophenyl)amino)-2-hydroxypropyl)isoindoline-1,3-dione
    3. CAS NO:874340-08-6
    4. Molecular Formula: C21H22FN3O4
    5. Molecular Weight: 399.4154832
    6. EINECS: N/A
    7. Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 874340-08-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.397
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol
    9. CAS DataBase Reference: N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline(874340-08-6)
    11. EPA Substance Registry System: N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline(874340-08-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 874340-08-6(Hazardous Substances Data)

874340-08-6 Usage

Uses

Used in Pharmaceutical Industry:
N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline is used as a key intermediate in the synthesis of Linezolid, an oxazolidinone antimicrobial agent. Its application is vital for the development of effective treatments against bacterial infections, as it contributes to the production of a drug that inhibits bacterial mRNA translation, thereby combating the spread of resistant bacteria.

Check Digit Verification of cas no

The CAS Registry Mumber 874340-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,3,4 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 874340-08:
(8*8)+(7*7)+(6*4)+(5*3)+(4*4)+(3*0)+(2*0)+(1*8)=176
176 % 10 = 6
So 874340-08-6 is a valid CAS Registry Number.

874340-08-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(2R)-3-(3-fluoro-4-morpholin-4-ylanilino)-2-hydroxypropyl]isoindole-1,3-dione

1.2 Other means of identification

Product number -
Other names 2-[(2R)-3-[[3-Fluoro-4-(4-morpholinyl)phenyl]amino]-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:874340-08-6 SDS

874340-08-6Relevant articles and documents

Preparation method of linezolid intermediate

-

Paragraph 0033-0085, (2021/03/11)

The invention discloses a preparation method of a linezolid intermediate. The preparation method comprises the following steps: by taking 3-fluoro-4- (4-morpholinyl) -aniline and 2- ((S) -3-chloro-2-hydroxypropyl) isoindoline-1, 3-diketone as main raw materials, carrying out substitution reaction in an amide dipole solvent at the temperature of 90-150 DEG C to obtain N- (3-phthalimido-2- (S) -hydroxypropyl) -3-fluoro-4- (morpholinyl) aniline which is an important intermediate for synthesizing the antibiotic linezolid. The preparation steps of the intermediate are simple, dangerous reagents such as butyl lithium, sodium azide, chloroformate and methylsulfonyl chloride which are inflammable, explosive and highly toxic in the conventional process are not used in the preparation process, and the safety is high; the main raw materials of 3-fluoro-4- (4-morpholinyl) -aniline and 2- ((S) -3-chloro-2-hydroxypropyl) isoindoline-1, 3-diketone are stable in source and low in cost, the used amidedipole solvent is easy to recycle, and the pollution to the environment can be reduced.

Linezolid related substance, and preparation method and application thereof

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Paragraph 0072-0080, (2020/09/12)

The invention belongs to the technical field of medicine synthesis, and discloses a linezolid related substance, and a preparation method and application thereof. The related substance is a compound Iwith a chemical formula of C17H24FN3O4, and the prepara

Synthesis of antibiotic linezolid analogues

Reddy, Pingili Krishna,Mukkanti,Rao, Dodda Mohan

scheme or table, p. 3479 - 3482 (2012/07/28)

Several new compounds of oxazolidinone class were designed, synthesized and their analogs were evaluated for antibacterial activity against Staphylococcus aureus, Staphylococcus citreus, Proteus vulgaris, Salmonella typhimurium and Klabsiella phenumoniae. The structures of all the compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral data.

NOVEL INTERMEDIATES FOR LINEZOLID AND RELATED COMPOUNDS

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Page/Page column 11, (2008/06/13)

The present invention provides a novel process for preparation of 5-aminomethyl substituted oxazolidinones, key intermediates for oxazolidinone antibacterials including linezolid. Thus, the key intermediate of linezolid is prepared by a) reacting N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyI aniline with potassium phthalimide; b) subjecting N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl) aniline produced in the above step to carbonylation; and c) reacting (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidiriyl] methyl]phthalimide produced in the above step with hydrazine hydrate to produce (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl] methyl]amine.

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