86-58-8Relevant articles and documents
NOVEL PYRIDIN-2(1H)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF PAIN
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Page/Page column 15; 23, (2021/04/10)
The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.
Silicon-bridged metallocene complex containing nitrogen heterocyclic ring structures and application thereof
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Paragraph 0045-0048, (2020/06/04)
The invention relates to a preparation method and application of an olefin polymerization reaction catalyst, in particular to a silicon-bridged metallocene complex with nitrogen heterocyclic ring structures and application thereof. Molecules of the designed novel silicon-bridged metallocene complex contain three different nitrogen heterocyclic ring structures, and the distances from nitrogen atomsto a metal center are different, so that different chemical environments are provided for the metal center, and the metallocene complex with a novel structure is constructed. By changing a skeleton structure and a substituent group, the three-dimensional effect and the electronic effect of the metallocene complex can be conveniently regulated and controlled, the catalytic performance is regulatedand controlled, and polyolefin high polymer materials with different structures and properties are prepared.
Silicon-bridged metallocene complex with C2 symmetrical structure and application thereof
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Paragraph 0037-0040, (2020/06/09)
The invention relates to a preparation method and application of an olefin polymerization reaction catalyst, in particular to a silicon-bridged metallocene complex with a C2 symmetrical structure andapplication thereof. Molecules of the silicon-bridged metallocene complex with the novel C2 symmetric structure in the invention contain seven different ligand structures, and ligands have chemical groups with different electron donating capacities, so different chemical environments are provided for a metal center, and the metallocene complex with the novel structure is constructed. By changing askeleton structure and substituent groups, the three-dimensional effect and the electronic effect of the metallocene complex can be conveniently regulated and controlled, so the catalytic performanceis regulated and controlled, and polyolefin high polymer materials with different structures and properties are prepared.
Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia
Abrunhosa-Thomas, Isabelle,Anizon, Fabrice,Artola, Alain,Dallel, Radhouane,Descheemaeker, Amélie,Giraud, Francis,Moreau, Pascale,Nauton, Lionel,Pinto-Pardo, Nicolas,Théry, Vincent,Visseq, Alexia
, (2019/12/24)
Mechanical Allodynia (MA), a frequent chronic pain symptom caused by innocuous stimuli, constitutes an unmet medical need, as treatments using analgesics available today are not always effective and can be associated with important side-effects. A series of 3,5-disubstituted pyridin-2(1H)-ones was designed, synthesized and evaluated in vivo toward a rat model of inflammatory MA. We found that the series rapidly and strongly prevented the development of MA. 3-(2-Bromophenyl)-5-(phenylamino)pyridin-2(1H)-one 69, the most active compound of the series, was also able to quickly reverse neuropathic MA in rats. Next, when 69 was evaluated toward a panel of 50 protein kinases (PK) in order to identify its potential biological target(s), we found that 69 is a p38α MAPK inhibitor, a PK known to contribute to pain hypersensitivity in animal models. 3,5-Disubstituted pyridin-2(1H)-ones thus could represent a novel class of analgesic for the treatment of MA.
COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
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Paragraph 0248; 0249, (2016/09/12)
A compound represented by Formula 1 or Formula 2, and an organic light-emitting device including a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer and the compound represented by Formula 1 or Formula 2.
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
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Paragraph 0157; 0166; 0168, (2016/10/07)
The present invention provides a novel compound capable of improving light emitting efficiency, stability and lifespan of an element, an organic electronic element using the same and an electronic device thereof.(110) Substrate(120) Positive electrode(130) Hole injection layer(140) Hole transfer layer(141) Buffer layer(150) Light emitting layer(151) Light-emitting assisting layer(160) Electron transfer layer(170) Electron injection layer(180) Negative electrodeCOPYRIGHT KIPO 2016
Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor
Newby, James A.,Huck, Lena,Blaylock, D. Wayne,Witt, Paul M.,Ley, Steven V.,Browne, Duncan L.
, p. 263 - 271 (2014/01/17)
Conducting low-temperature organometallic reactions under continuous flow conditions offers the potential to more accurately control exotherms and thus provide more reproducible and scalable processes. Herein, progress towards this goal with regards to the lithium-halogen exchange/borylation reaction is reported. In addition to improving the scope of substrates available on a research scale, methods to improve reaction profiles and expedite purification of the products are also described. On moving to a continuous system, thermocouple measurements have been used to track exotherms and provide a level of safety for continuous processing of organometallic reagents. The use of an in-line continuous liquid-liquid separation device to circumvent labour intensive downstream off-line processing is also reported. A cool setup: A small footprint, modular setup based around a cryo-flow reactor is reported for the preparation of gram quantities of boronic esters. With minimum alteration, including the addition of a data logger with thermocouples and a liquid-liquid separator, the same equipment can be used to scale the process, inclusive of an in-line extraction. Copyright
Synthesis of functionalized porphyrins as oxygen ligand receptors
Wada, Kenji,Mizutani, Tadashi,Kitagawa, Susumu
, p. 5123 - 5131 (2007/10/03)
Oxophilic synthetic receptors were designed and synthesized using a porphyrin scaffold, with the aim of constructing a preorganized complementary binding site for phenols and carbohydrates. We pursued three strategies for phenol recognition: (1) Lewis aci
