72707-66-5Relevant articles and documents
Artificial [FeFe]-hydrogenase: On resin modification of an amino acid to anchor a hexacarbonyldiiron cluster in a peptide framework
Roy, Souvik,Shinde, Sandip,Hamilton, G. Alexander,Hartnett, Hilairy E.,Jones, Anne K.
experimental part, p. 1050 - 1055 (2011/06/10)
A general method for immobilization of synthetic analogues of the [FeFe]-hydrogenase in designed peptides via on resin modification of an amino acid side chain with a dithiol functional group is described. Utilizing a unique amine side chain as anchor, the dithiol unit is coupled to the peptide via formation of an amide. This dithiol unit precisely positions the two required sulfur atoms for the formation of a [(μ-SRS){Fe-(CO)3} 2] cluster on reaction with [Fe3(CO)12]. UV/Vis and FTIR spectroscopy demonstrate formation of the desired complex.
Practical preparation of 2-halomethyl-allyl carboxylates
Sun, Chong-Si,Cheng, Hsiu-Yi,Lin, Yu-Shiang,Hou, Duen-Ren
, p. 435 - 438 (2008/12/22)
An improved, efficient preparation of 2-(halomethyl)allyl carboxylates starting from diethyl bis(hydroxymethyl) malonate and hydrobromic acid is reported. The allylic halogen of 2-(chloromethyl)acrylate and 2-(bromomethyl)acrylate are readily exchanged during esterification.
Radiochemical 18F-fluoroarylation of unsaturated α-, β- and γ-amino acids, application to a radiolabelled analogue of baclofen
H?fling, Sarah B.,Hultsch, Christina,Wester, Hans-Jürgen,Heinrich, Markus R.
experimental part, p. 11846 - 11851 (2009/04/06)
Unsaturated α-, β- and γ-amino acids have been investigated as substrates for the reductive Meerwein arylation. Radical reactions of this type have been shown to be a valuable tool for the fast and efficient introduction of the 4-[18F]fluorophenyl group into precursor molecules allowing short-time syntheses of potential PET radiotracers, which would be more difficult to access by other methods.
Bromination of organic allylic compounds by using N,N′-dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine
Khazaei, Ardeshir,Vaghei, Ramin Ghorbani,Karkhanei, Ebrahim
, p. 2107 - 2113 (2007/10/03)
N,N′-Dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine is an efficient brominating agent for bromination of allylic positions of different organic compounds. This reagent in presence of benzoyl peroxide can brominates the allylic positions of organic compounds in ambient conditions in carbon tetrachloride.
Amino acid, derivatives, processes for their preparation and their therapeutic application
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, (2008/06/13)
New amino acid derivatives, processes for their preparation and their therapeutic application. Amino acid derivatives corresponding to the general formulae STR1 These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
Comparisons of rate constants for thiolate-disulfide interchange in water and in polar aprotic solvents using dynamic 1H NMR line shape analysis
Singh, Rajeeva,Whitesides, George M.
, p. 1190 - 1197 (2007/10/02)
The rate constants for representative thiolate-disulfide interchange reactions are larger in DMSO and DMF than in water by a factor of approximately 2300 at 24 °C. The log of the rate constant is directly proportional to the mole fraction of D2O in mixtures of DMSO and D2O, even at small mole fractions of D2O. This linear proportionality suggests that thiolate anion is not specifically solvated by water and that hydrogen bonding is relatively unimportant in stabilizing this species. The values of ΔS# for thiolate-disulfide interchange are approximately -10 cal/(deg mol), presumptively because of loss in the entropy of the reactants in going from ground to transition state, partially compensated by a gain in entropy from solvent release. Introduction of a hydroxyl group β to the C-S bond slows the reaction by a factor of 2-15; the introduction of methyl groups β to the C-S bond slows the rate by factors of 3-20. A number of substances have been screened as potential catalysts for thiolate-disulfide interchange in water: none showed useful levels of catalytic activity, although phenylselenol did accelerate the interchange significantly.
