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CAS

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Climbazole is an imidazole antifungal agent that exhibits potent antifungal activity against various yeasts and dermatophytes. It effectively inhibits the growth of Candida albicans, Malassezia pachydermatis, and Malassezia furfur both in vitro and in vivo. Additionally, Climbazole has been shown to increase cytochrome P450 levels in rat liver, indicating its potential influence on drug metabolism.

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  • 38083-17-9 Structure

  • Basic information

    1. Product Name: Climbazole
    2. Synonyms: 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanon;1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-Butanone;bay-e6975;baypival;RadixAsteris;1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
    3. CAS NO:38083-17-9
    4. Molecular Formula: C15H17ClN2O2
    5. Molecular Weight: 292.76
    6. EINECS: 253-775-4
    7. Product Categories: Pesticide;Alpha sort;C;CAlphabetic;CI - CLPesticides;Conazoles;Fungicides;Pesticides&Metabolites;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 38083-17-9.mol

  • Chemical Properties

    1. Melting Point: 96-100°C
    2. Boiling Point: 447.5 °C at 760 mmHg
    3. Flash Point: 224.4 °C
    4. Appearance: off-white to pale yellow crystalline powder
    5. Density: 1.17 g/cm3
    6. Vapor Pressure: 3.34E-08mmHg at 25°C
    7. Refractive Index: 1.56
    8. Storage Temp.: -20°C Freezer
    9. Solubility: Insoluble in water
    10. PKA: 5.66±0.22(Predicted)
    11. Water Solubility: 58mg/L at 25℃
    12. BRN: 618020
    13. CAS DataBase Reference: Climbazole(CAS DataBase Reference)
    14. NIST Chemistry Reference: Climbazole(38083-17-9)
    15. EPA Substance Registry System: Climbazole(38083-17-9)

  • Safety Data

    1. Hazard Codes: Xn,N
    2. Statements: 22-50/53
    3. Safety Statements: 60-61
    4. RIDADR: UN 3077
    5. WGK Germany: 3
    6. RTECS: EL7085000
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 38083-17-9(Hazardous Substances Data)

38083-17-9 Usage

Uses

Used in Personal Care Industry:
Climbazole is used as an anti-dandruff agent for its ability to inhibit the growth of Malassezia yeast, a common cause of dandruff. When incorporated into a shampoo matrix, it provides anti-dandruff benefits, helping to reduce flaking and itching associated with this condition.
Used in Veterinary Medicine:
Climbazole is used as an antifungal treatment for dogs with skin infections caused by Malassezia yeast. When applied topically at a dose of 2% in shampoo, it effectively reduces the size of Malassezia populations on the skin of naturally infected dogs, improving their skin health.
Used in Toxicology Research:
Climbazole has been utilized in in vitro assays to study its potential genotoxic effects. It has been found to be non-genotoxic, as it did not induce micronuclei in human lymphocytes, suggesting its safety in certain applications.

Risks to the environment

Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.

Hazard

Moderately toxic by ingestion. Low toxicity by skin contact.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 38083-17-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,8 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38083-17:
(7*3)+(6*8)+(5*0)+(4*8)+(3*3)+(2*1)+(1*7)=119
119 % 10 = 9
So 38083-17-9 is a valid CAS Registry Number.
InChI:InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

38083-17-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • TCI America

  • (C2025)  Climbazole  >98.0%(HPLC)(T)

  • 38083-17-9

  • 25g

  • 260.00CNY

  • Detail

  • TCI America

  • (C2025)  Climbazole  >98.0%(HPLC)(T)

  • 38083-17-9

  • 500g

  • 1,900.00CNY

  • Detail

  • USP

  • (1135600)  Climbazole  United States Pharmacopeia (USP) Reference Standard

  • 38083-17-9

  • 1135600-400MG

  • 4,647.24CNY

  • Detail

38083-17-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name climbazole

1.2 Other means of identification

Product number -
Other names bay-e6975

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38083-17-9 SDS

38083-17-9Relevant articles and documents

Preparation method of climbazole

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Paragraph 0048; 0061; 0062; 0064; 0067; 0070; 0073, (2018/04/03)

The invention discloses a preparation method of climbazole. According to the method, toluene, chloroetherketone, imidazole and a catalyst, serving as raw materials, react under 100 DEG C to 110 DEG Cfor 4 hours while the temperature is kept, and then the climbazole with the purity being up to 99 percent is prepared by methods, such as crystallization, purification, alkaline wash and recrystallization. Through a lot of experiments, the invention screens out the best climbazole preparation method, the whole process design is reasonable, the process is easy and efficient to operate, in particular, the best reaction conditions screened out, which include catalyst variety, reaction solvent, reaction temperature, reaction time and steps, such as crude reaction of methylbenzene and the climbazole, and alkaline wash thereof, can greatly increase reaction yield (up to 92 percent or above), side reaction is reduced, the reaction rate is increased, the production cost is greatly reduced, and therefore the preparation method of the climbazole has a good application prospect.

NOVEL NEISSERIA MENINGITIDIS SEROGROUP Y OLIGOMER AND PROCESS FOR SYNTHESIZING THEREOF

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Paragraph 0048; 0061; 0064; 0067; 0070; 0073, (2018/04/03)

The present invention relates to novel oligomers of Neisseria meningitidis serogroup Y capsular polysaccharide repeating unit (Men-Y oligomers) and process for synthesizing novel Men- Y oligomers. Inparticular, the present invention relates to the chemical synthesis of the tetramer of Men- Y capsular polysaccharide repeating unit capable of being used as a candidate in the development of semisynthetic or fully synthetic conjugate vaccine against meningococcal serogroup Y bacterial infection.

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