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CAS

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AIDS031406, also known as N-(4-acetamido-2-[(4-hydroxyphenyl)sulfonyl] phenyl)-2-[(4-hydroxyphenyl)sulfonyl] benzamide, is a sulfonamide derivative with potential antineoplastic and anti-inflammatory activities. It functions as an inhibitor of the enzyme carbonic anhydrase IX (CAIX), which is overexpressed in hypoxic tumor cells and contributes to tumor cell survival and growth. By inhibiting CAIX, AIDS031406 may help reduce tumor hypoxia and inhibit tumor cell proliferation. It is being studied for its potential use in the treatment of certain types of cancer, as well as other conditions involving inflammation and hypoxia, although further research is still needed to fully understand its therapeutic potential.

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  • 2H-Pyran-5-carboxylic acid,4-[[(1R)-2-acetyl-1,2,3,4-tetrahydro-6,- 7-dihydroxy-1-isoquinolinyl]methyl]-3- ethenyl-2-(a-D-glucopyranosyloxy)-3,4- dihydro-,methyl ester,(2S,3R,4S)-

    Cas No: 15401-60-2

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  • 2H-Pyran-5-carboxylic acid, 4-[(2-acetyl-1,2,3,4-tetrahydro-6,7-dihydroxy-1-isoquinolinyl)methyl]-3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-, methyl ester, [2S-[2α,3β,4β(S*)]]-Ipecoside (6CI

    Cas No: 15401-60-2

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  • 15401-60-2 Structure
  • Basic information

    1. Product Name: AIDS031406
    2. Synonyms: AIDS031406;(2S)-4α-[[(1R)-2-Acetyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinolin-1-yl]methyl]-3α-vinyl-2β-(β-D-glucopyranosyloxy)-3,4-dihydro-2H-pyran-5-carboxylic acid methyl ester;Ipecoside;2H-Pyran-5-carboxylic acid, 4-[(2-acetyl-1,2,3,4-tetrahydro-6,7-dihydroxy-1-isoquinolinyl)methyl]-3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-, methyl ester, [2S-[2α,3β,4β(S*)]]-Ipecoside (6CI,8CI);NSC 603972
    3. CAS NO:15401-60-2
    4. Molecular Formula: C27H35NO12
    5. Molecular Weight: 565.5663
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 15401-60-2.mol
  • Chemical Properties

    1. Melting Point: 175 °C (approx)
    2. Boiling Point: 821.6°Cat760mmHg
    3. Flash Point: 450.7°C
    4. Appearance: /
    5. Density: 1.5g/cm3
    6. Vapor Pressure: 1.42E-28mmHg at 25°C
    7. Refractive Index: 1.65
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.53±0.40(Predicted)
    11. CAS DataBase Reference: AIDS031406(CAS DataBase Reference)
    12. NIST Chemistry Reference: AIDS031406(15401-60-2)
    13. EPA Substance Registry System: AIDS031406(15401-60-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 15401-60-2(Hazardous Substances Data)

15401-60-2 Usage

Uses

Used in Oncology:
AIDS031406 is used as an antineoplastic agent for its potential to inhibit the enzyme carbonic anhydrase IX (CAIX), which is overexpressed in hypoxic tumor cells. This inhibition may help reduce tumor hypoxia and inhibit tumor cell proliferation, making it a promising candidate for the treatment of certain types of cancer.
Used in Anti-inflammatory Applications:
AIDS031406 is used as an anti-inflammatory agent due to its potential to modulate inflammation and hypoxia, which are often associated with various inflammatory conditions. By targeting these pathways, AIDS031406 may offer therapeutic benefits in managing inflammation-related disorders.
Used in Drug Development:
AIDS031406 is used as a research compound for further investigation of its therapeutic potential in treating cancer and other conditions involving inflammation and hypoxia. Ongoing research aims to better understand its mechanism of action, efficacy, and safety profile, which will inform its development as a potential drug candidate.

Check Digit Verification of cas no

The CAS Registry Mumber 15401-60-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,4,0 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 15401-60:
(7*1)+(6*5)+(5*4)+(4*0)+(3*1)+(2*6)+(1*0)=72
72 % 10 = 2
So 15401-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H35NO12/c1-4-14-16(8-18-15-9-20(32)19(31)7-13(15)5-6-28(18)12(2)30)17(25(36)37-3)11-38-26(14)40-27-24(35)23(34)22(33)21(10-29)39-27/h4,7,9,11,14,16,18,21-24,26-27,29,31-35H,1,5-6,8,10H2,2-3H3/t14-,16+,18-,21-,22-,23+,24-,26+,27+/m1/s1

15401-60-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (2S)-4-[[(1R)-2-acetyl-6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-3-ethenyl-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15401-60-2 SDS

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