115436-72-1 Usage
References
[1] https://www.medicines.org.uk
[2] http://www.rxlist.com
[3] http://www.healthline.com
Originator
Procter Gamble (US)
Hazard
Human systemic effects.
Biological Activity
Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase. Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone reabsorption in vivo .
Biochem/physiol Actions
Risedronate sodium is a bisphosphonate bone resorption inhibitor. It has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent and is an inhibitor of farnesyl diphosphate (FPP) synthase, which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. Risedronate sodium has been used to treat postmenopausal osteoporosis and Paget′s disease.
Clinical Use
Bisphosphonate:
Treatment and prevention of osteoporosis (including
corticosteroid induced)
Paget’s disease
Drug interactions
Potentially hazardous interactions with other drugs
Calcium-containing substances: avoid for 2 hours
before and after administration.
Metabolism
The mean bioavailability of risedronate is 0.63% in
the fasting state, and there is no evidence of systemic
metabolism of risedronate sodium.
About half of the absorbed portion is excreted in the
urine within 24 hours; the remainder is sequestered
to bone for a prolonged period. Unabsorbed drug is
eliminated unchanged in the faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 115436-72-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,3 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115436-72:
(8*1)+(7*1)+(6*5)+(5*4)+(4*3)+(3*6)+(2*7)+(1*2)=111
111 % 10 = 1
So 115436-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);
